The material expands Evonik’s existing portfolio of biomaterials for implants in long-term contact with the body, offering a metal-free alternative to titanium implants. This review covers all FDA-approved bone regeneration therapies such as the 'gold standard' autografts, allografts, synthetic bone grafts, and the newer growth factors/bioactive molecules. Specialty chemicals company Evonik has developed a new osteoconductive polyether ether ketone (PEEK) that improves bone-implant fusion. There is a need of a bone regeneration method of similar quality of an autograft that is osteoconductive, osteoinductive, and osteogenic. Polyetheretherketone (PEEK) is a high-performance, semi-crystalline engineering thermoplastic material that is an excellent choice for demanding applications.It withstands high temperatures and is resistant to chemicals and radiation. Growth factors and bioactive molecules show some promising results in bone regeneration, although more research is needed to avoid their adverse effects and learn about the long-term effects of these therapies. P-15 was found to be effective, safe, and have similar outcomes to autograft at 2 years post-op for cervical radiculopathy due to cervical degenerative disc disease. There is also an FDA-approved bioactive molecule for bone regeneration, a peptide P-15. PDGF-BB grafts in studies have shown PDGF had similar fusion rates to autologous grafts and fewer adverse effects. PEEK is used as an alternative to titanium in spinal implants because it has a similar structure of bones and it can be. BMP-7 is no longer an option for bone regeneration as it has withdrawn off the market. DiFusion Technologies has chosen to use Solvay ’s Zeniva ZA-500 polyetheretherketone (PEEK) as the base polymer for its ZFUZE osteoconductive PEEK composite used in spinal implants. BMP-2 may also be advantageous for patients not willing to give up smoking as it shows bone regeneration success with smokers. BMP-2 has many adverse effects such as inflammatory complications such as massive soft-tissue swelling that can compromise a patient's airway, ectopic bone formation, and tumor formation. Although, BMP shows promising results as being an alternative to autograft, it also has its own downfalls. Growth factors such as recombinant BMP-2, BMP-7, and PDGF are FDA-approved therapies in bone regeneration. Initially focusing on the multi-billion dollar spinal implant market, the company has developed a technology with applicability across a variety of orthopedic segments using well characterized implants with benefits for the patient, surgeon, hospital and payer.To induce bone regeneration there is a complex cascade of growth factors. is a medical device company focused on reducing the rising incidence of surgical site infections in orthopedic and spine surgery through the development of a suite of patented antimicrobial orthobiologic polymeric implants. Solvay SA ( SOLB.BE) is listed on Euronext Brussels and Paris (Bloomberg: SOLB.BB – Reuters: SOLB.BR) and in the United States its shares (SOLVY) are traded through a level-1 ADR program.įounded in 2008 in Austin, Tex., DiFusion Technologies, Inc.

Net sales were € 10.9 billion in 2016, with 90% from activities where Solvay ranks among the world’s top 3 leaders. Solvay is headquartered in Brussels with around 27,000 employees in 58 countries. Its lightweighting materials enhance cleaner mobility, its formulations optimize the use of resources and its performance chemicals improve air and water quality. Karen Schoelles, MD, SM, FACP Vice President, Clinical Excellence and Safety. Its products and solutions are used in planes, cars, smart and medical devices, batteries, in mineral and oil extraction, among many other applications promoting sustainability. Solvay innovates and partners with customers in diverse global end markets. Our first product ZFUZE was developed as a load-bearing osteoconductive biomaterial platform for orthopedic applications, proven highly successful in 2 large animal studies. Learn more at Solvay is a multi-specialty chemical company, committed to developing chemistry that addresses key societal challenges. Solvay Specialty Polymers manufactures over 1500 products across 35 brands of high-performance polymers – fluoropolymers, fluoroelastomers, fluorinated fluids, semi-aromatic polyamides, sulfone polymers, aromatic ultra-high performance polymers, and high barrier polymers – for use in Aerospace, Alternative Energy, Automotive, Healthcare, Membranes, Oil and Gas, Packaging, Plumbing, Semiconductors, Wire & Cable, and other industries.

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